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ea0029p10 | Adrenal cortex | ICEECE2012

The mTOR-pathway in normal and tumoral human adrenocortical tissues

De Martino M. , van Koetsveld P. , Feelders R. , Sprij-Mooij D. , Waaijers M. , Lamberts S. , de Herder W. , Colao A. , de Krijger R. , Pivonello R. , Hofland L.

Background: Novel treatment options are required for patients with adrenocortical carcinomas (ACCs). mTOR-inhibitors are anti-neoplastic drugs that target the mTOR-pathway.Aim: To describe the expression of the mTOR-pathway in normal and pathological adrenocortical tissues.Methods: We evaluated mRNA expression levels of mTOR, S6K and 4EBP1 in 10 normal adrenals (NA), 11 adrenal hyperplasias (AH), 19 adrenal adenomas (ACA) and 26 AC...

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ea0029p1073 | Neuroendocrinology | ICEECE2012

Normalization of cortisol levels in Cushing's disease after medical pretreatment before surgery: effects on somatostatin receptor subtype expression and in vitro response to somatostatin analogs.

Pas R. van der , Feelders R. , Bruin C. de , Pereira A. , Sprij-Mooij D. , Waaijers M. , Schulz S. , Lamberts S. , Hofland L.

Introduction: Corticotroph pituitary adenomas that cause Cushings disease (CD) predominantly express the dopamine 2 receptor (D2) and somatostatin receptor subtype (sst) 5. The expression of sst2 is relatively low because of downregulating effects of high endogenous cortisol levels. This may explain why the sst2-preferring somatostatin analog octreotide is not effective in CD. To assess whether normalization of urinary free cortisol (UFC) excretion modulates the sst expr...

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Endocrine Abstracts

The mTOR-pathway in normal and tumoral human adrenocortical tissues

Normalization of cortisol levels in Cushing's disease after medical pretreatment before surgery: effects on somatostatin receptor subtype expression and in vitro response to somatostatin analogs.

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